Selected publications

Moisio O, Virta J, Yatkin E, Liljenbäck H, Palani S, Viitanen R, Miner MWG, Oikonen V, Tolvanen T, Vugts DJ, Taimen P, Li XG, Hollmén M, Jalkanen S, Roivainen A. (2023) Preclinical Evaluation of 89Zr-Desferrioxamine-Bexmarilimab, a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, in a Rabbit Model of Renal Fibrosis. J Nucl Med. 64:555-560.

Miner MWG, Liljenbäck H, Virta J, Kärnä S, Viitanen R, Elo P, Gardberg M, Teuho J, Saipa P, Rajander J, Mansour HMA, Cleveland NA, Low PS, Li XG, Roivainen A. (2023) High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities. Front Immunol. 18;14:1145473.

Sun L, Aarnio R, Herre EA, Kärnä S, Palani S, Virtanen H, Liljenbäck H, Virta J, Honkaniemi A, Oikonen V, Han C, Laurila S, Bucci M, Helin S, Yatkin E, Nummenmaa L, Nuutila P, Tang J, Roivainen A. (2023) [11C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue. Eur J Nucl Med Mol Imaging. 50:266-274.

Örd T, Lönnberg T, Nurminen V, Ravindran A, Niskanen H, Kiema M, Õunap K, Maria M, Moreau PR, Mishra PP, Palani S, Virta J, Liljenbäck H, Aavik E, Roivainen A, Ylä-Herttuala S, Laakkonen JP, Lehtimäki T, Kaikkonen MU. (2023) Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures. Am J Hum Genet. 110:722-740.

Jahandideh A, Uotila S, Ståhle M, Virta J, Li XG, Kytö V, Marjamäki P, Liljenbäck H, Taimen P, Oikonen V, Lehtonen J, Mäyränpää MI, Chen Q, Low PS, Knuuti J, Roivainen A, Saraste A

(2020)

Folate Receptor β-Targeted PET Imaging of Macrophages in Autoimmune Myocarditis.

J Nucl Med
61:1643-1649.


Viitanen R, Moisio OA, Lankinen P, Li XG, Koivumäki M, Suilamo S, Tolvanen T, Taimen K, Mali M, Kohonen I, Koskivirta I, Oikonen V, Virtanen H, Santalahti K, Autio A, Saraste A, Pirilä L, Nuutila P, Knuuti J, Jalkanen S, Roivainen A

(2020)

First-in-Humans Study of 68 Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1.

J Nucl Med
62:577-583.


Siitonen R, Pietikäinen A, Liljenbäck H, Käkelä M, Söderström M, Jalkanen S, Hytönen J, Roivainen A

(2017)

Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice.

Arthritis Res Ther
19:254.


Silvola JMU, Virtanen H, Siitonen R, Hellberg S, Liljenbäck H, Metsälä O, Ståhle M, Saanijoki T, Käkelä M, Hakovirta H, Ylä-Herttuala S, Saukko P, Jauhiainen M, Veres TZ, Jalkanen S, Knuuti J, Saraste A, Roivainen A

(2016)

Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques.

Sci Rep
6:35089


Haavisto M, Saraste A, Pirilä L, Hannukainen JC, Kalliokoski KK, Kirjavainen A, Kemppainen J, Möttönen T, Knuuti J, Yli-Kerttula T, Roivainen A

(2016)

Influence of triple disease modifying anti-rheumatic drug therapy on carotid artery inflammation in drug-naive patients with recent onset of rheumatoid arthritis.

Rheumatol
55:1777-1785.


Aalto K, Autio A, Kiss EA, Elima K, Nymalm Y, Veres TZ, Marttila-Ichihara F, Elovaara H, Saanijoki T, Crocker PR, Maksimow M, Bligt E, Salminen TA, Salmi M, Roivainen A, Jalkanen S

(2011)

Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be utilized in PET-imaging of inflammation and cancer.

Blood
118:3725–3733.

Publications by year

Dillemuth P, Lövdahl P, Karskela T, Ayo A, Ponkamo J, Liljenbäck H, Paunonen S, Kunnas J, Rajander J, Tynninen O, Rosenholm JM, Roivainen A, Laakkonen P, Airaksinen AJ, Li XG (2024) Switching the Chemoselectivity in the Preparation of [(18)F]FNA-N-CooP, a Free Thiol-Containing Peptide for Targeted Positron Emission Tomography Imaging of Fatty Acid Binding Protein 3.  Mol Pharm.

Bellman J, Sjöros T, Hägg D, Atencio Herre E, Hieta J, Eskola O, Laitinen K, Nuutila P, Jansson JO, Jansson PA, Kalliokoski K, Roivainen A, Ohlsson C (2024) Loading enhances glucose uptake in muscles, bones, and bone marrow of lower extremities in humans.  J Clin Endocrinol Metab.

Hess S, Noriega-Álvarez E, Leccisotti L, Treglia G, Albano D, Roivainen A, Glaudemans AWJM, Gheysens O (2024) EANM consensus document on the use of [(18)F]FDG PET/CT in fever and inflammation of unknown origin.  Eur J Nucl Med Mol Imaging 51(9):2597-2613.

Saraste A, Ståhle M, Roivainen A, Knuuti J (2024) Molecular Imaging of Heart Failure: An Update and Future Trends.  Semin Nucl Med.

Andriana P, Fair-Mäkelä R, Liljenbäck H, Kärnä S, Iqbal I, Makrypidi K, Rajander J, Pirmettis I, Li XG, Jalkanen S, Saraste A, Salmi M, Roivainen A (2024) Macrophage mannose receptor CD206 targeting of fluoride-18 labeled mannosylated dextran: A validation study in mice.  Eur J Nucl Med Mol Imaging 51(8):2216-2228.

Dillemuth P, Karskela T, Ayo A, Ponkamo J, Kunnas J, Rajander J, Tynninen O, Roivainen A, Laakkonen P, Airaksinen AJ, Li XG (2024) Radiosynthesis, structural identification and in vitro tissue binding study of [(18)F]FNA-S-ACooP, a novel radiopeptide for targeted PET imaging of fatty acid binding protein 3.  EJNMMI Radiopharm Chem 9(1):16.

Bhowmik AA, Heikkilä TRH, Polari L, Virta J, Liljenbäck H, Moisio O, Li XG, Viitanen R, Jalkanen S, Koffert J, Toivola DM, Roivainen A (2024) Detection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [(68)Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease.  Mol Imaging Biol 26(2):322-333.

Nammas W, Paunonen C, Teuho J, Siekkinen R, Luoto P, Käkelä M, Hietanen A, Viljanen T, Dietz M, Prior JO, Li XG, Roivainen A, Knuuti J, Saraste A (2024) Imaging of Myocardial α(v)β(3) Integrin Expression for Evaluation of Myocardial Injury After Acute Myocardial Infarction.  J Nucl Med 65(1):132-138.

Auchynnikava T, Äärelä A, Liljenbäck H, Järvinen J, Andriana P, Kovacs L, Rautio J, Rajander J, Virta P, Roivainen A, Li XG, Airaksinen AJ (2023) Tetrazine Glycoconjugate for Pretargeted Positron Emission Tomography Imaging of trans-Cyclooctene-Functionalized Molecular Spherical Nucleic Acids.  ACS Omega 8(48):45326-45336.

Jahandideh A, Virta J, Li XG, Liljenbäck H, Moisio O, Ponkamo J, Rajala N, Alix M, Lehtonen J, Mäyränpää MI, Salminen TA, Knuuti J, Jalkanen S, Saraste A, Roivainen A (2023) Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis.  J Nucl Cardiol 30(6):2760-2772.

Äärelä A, Auchynnikava T, Moisio O, Liljenbäck H, Andriana P, Iqbal I, Lehtimäki J, Rajander J, Salo H, Roivainen A, Airaksinen AJ, Virta P (2023) In Vivo Imaging of [60]Fullerene-Based Molecular Spherical Nucleic Acids by Positron Emission Tomography.  Mol Pharm 20(10):5043-5051.

Miner MWG, Liljenbäck H, Virta J, Kärnä S, Viitanen R, Elo P, Gardberg M, Teuho J, Saipa P, Rajander J, Mansour HMA, Cleveland NA, Low PS, Li XG, Roivainen A (2023) High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities.  Front Immunol 14:1145473.

Örd T, Lönnberg T, Nurminen V, Ravindran A, Niskanen H, Kiema M, Õunap K, Maria M, Moreau PR, Mishra PP, Palani S, Virta J, Liljenbäck H, Aavik E, Roivainen A, Ylä-Herttuala S, Laakkonen JP, Lehtimäki T, Kaikkonen MU (2023) Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures.  Am J Hum Genet 110(5):722-740.

Andriana P, Makrypidi K, Liljenbäck H, Rajander J, Saraste A, Pirmettis I, Roivainen A, Li XG (2023) Aluminum Fluoride-18 Labeled Mannosylated Dextran: Radiosynthesis and Initial Preclinical Positron Emission Tomography Studies.  Mol Imaging Biol 25(6):1094-1103.

Moisio O, Virta J, Yatkin E, Liljenbäck H, Palani S, Viitanen R, Miner MWG, Oikonen V, Tolvanen T, Vugts DJ, Taimen P, Li XG, Hollmén M, Jalkanen S, Roivainen A (2023) Preclinical Evaluation of (89)Zr-Desferrioxamine-Bexmarilimab, a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, in a Rabbit Model of Renal Fibrosis.  J Nucl Med 64(4):555-560.

Sun L, Aarnio R, Herre EA, Kärnä S, Palani S, Virtanen H, Liljenbäck H, Virta J, Honkaniemi A, Oikonen V, Han C, Laurila S, Bucci M, Helin S, Yatkin E, Nummenmaa L, Nuutila P, Tang J, Roivainen A (2023) [(11)C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue.  Eur J Nucl Med Mol Imaging 50(2):266-274.

Viitanen R, Virtanen H, Liljenbäck H, Moisio O, Li XG, Nicolini V, Richard M, Klein C, Nayak T, Jalkanen S, Roivainen A (2022) [(68)Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice.  Front Immunol 13:901693.

Otaru S, Paulus A, Imlimthan S, Kuurne I, Virtanen H, Liljenbäck H, Tolvanen T, Auchynnikava T, Roivainen A, Helariutta K, Sarparanta M, Airaksinen AJ (2022) Development of [(18)F]AmBF(3) Tetrazine for Radiolabeling of Peptides: Preclinical Evaluation and PET Imaging of [(18)F]AmBF(3)-PEG(7)-Tyr(3)-Octreotide in an AR42J Pancreatic Carcinoma Model.  Bioconjug Chem 33(7):1393-1404.

Suilamo S, Li XG, Lankinen P, Oikonen V, Tolvanen T, Luoto P, Viitanen R, Saraste A, Seppänen M, Pirilä L, Hohenthal U, Roivainen A (2022) (68)Ga-Citrate PET of Healthy Men: Whole-Body Biodistribution Kinetics and Radiation Dose Estimates.  J Nucl Med 63(10):1598-1603.

Roivainen A, Ståhle M, Saraste A (2022) Positron Emission Tomography in Atherosclerosis Research.  Methods Mol Biol 2419:825-839.

Palani S, Miner MWG, Virta J, Liljenbäck H, Eskola O, Örd T, Ravindran A, Kaikkonen MU, Knuuti J, Li XG, Saraste A, Roivainen A (2022) Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-(18)F-Fluoroglutamine.  Front Immunol 13:821423.

Jahandideh A, Ståhle M, Virta J, Li XG, Liljenbäck H, Moisio O, Knuuti J, Roivainen A, Saraste A (2021) Evaluation of [(68)Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis.  Front Med (Lausanne) 8:783596.

Miner MWG, Liljenbäck H, Virta J, Helin S, Eskola O, Elo P, Teuho J, Seppälä K, Oikonen V, Yang G, Kindler-Röhrborn A, Minn H, Li XG, Roivainen A (2021) Comparison of: (2S,4R)-4-[(18)F]Fluoroglutamine, [(11)C]Methionine, and 2-Deoxy-2-[(18)F]Fluoro-D-Glucose and Two Small-Animal PET/CT Systems Imaging Rat Gliomas.  Front Oncol 11:730358.

Niiranen L, Mäkelä KA, Mutt SJ, Viitanen R, Kaisanlahti A, Vicente D, Noponen T, Autio A, Roivainen A, Nuutila P, Saarela S, Herzig KH (2021) Role of Brown and Beige Adipose Tissues in Seasonal Adaptation in the Raccoon Dog (Nyctereutes procyonoides).  Int J Mol Sci 22.

Grönman M, Moisio O, Li XG, Toimela T, Huttala O, Heinonen T, Knuuti J, Roivainen A, Saraste A (2021) Association between [(68)Ga]NODAGA-RGDyK uptake and dynamics of angiogenesis in a human cell-based 3D model.  Mol Biol Rep 48(6):5347-5353.

Merisaari H, Laakso H, Liljenbäck H, Virtanen H, Aronen HJ, Minn H, Poutanen M, Roivainen A, Liimatainen T, Jambor I (2021) Statistical Evaluation of Different Mathematical Models for Diffusion Weighted Imaging of Prostate Cancer Xenografts in Mice.  Front Oncol 11:583921.

Gulumkar V, Äärelä A, Moisio O, Rahkila J, Tähtinen V, Leimu L, Korsoff N, Korhonen H, Poijärvi-Virta P, Mikkola S, Nesati V, Vuorimaa-Laukkanen E, Viitala T, Yliperttula M, Roivainen A, Virta P (2021) Controlled Monofunctionalization of Molecular Spherical Nucleic Acids on a Buckminster Fullerene Core.  Bioconjug Chem 32(6):1130-1138.

Ståhle M, Hellberg S, Virta J, Liljenbäck H, Metsälä O, Li XG, Jauhiainen M, Saukko P, Ylä-Herttuala S, Nuutila P, Knuuti J, Saraste A, Roivainen A (2021) Evaluation of glucagon-like peptide-1 receptor expression in nondiabetic and diabetic atherosclerotic mice using PET tracer (68)Ga-NODAGA-exendin-4.  Am J Physiol Endocrinol Metab 320(5):E989-E998.

Laakso H, Ylä-Herttuala E, Sierra A, Jambor I, Poutanen M, Liljenbäck H, Virtanen H, Merisaari H, Aronen H, Minn H, Roivainen A, Liimatainen T (2021) Docetaxel chemotherapy response in PC3 prostate cancer mouse model detected by rotating frame relaxations and water diffusion.  NMR Biomed 34(4):e4483.

Elo P, Li XG, Liljenbäck H, Gardberg M, Moisio O, Miner M, Virta J, Saraste A, Srinivasarao M, Pugh M, Low PS, Knuuti J, Jalkanen S, Airas L, Lu YJ, Roivainen A (2021) Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis.  J Neuroinflammation 18(1):30.

Sun L, Tang J, Liljenbäck H, Honkaniemi A, Virta J, Isojärvi J, Karjalainen T, Kantonen T, Nuutila P, Hietala J, Kaasinen V, Kalliokoski K, Hirvonen J, Scheinin H, Helin S, Eerola K, Savontaus E, Yatkin E, Rinne JO, Roivainen A, Nummenmaa L (2021) Seasonal Variation in the Brain μ-Opioid Receptor Availability.  J Neurosci 41(6):1265-1273.

Sokolowska E, Viitanen R, Misiewicz Z, Mennesson M, Saarnio S, Kulesskaya N, Kängsep S, Liljenbäck H, Marjamäki P, Autio A, Callan SA, Nuutila P, Roivainen A, Partonen T, Hovatta I (2021) The circadian gene Cryptochrome 2 influences stress-induced brain activity and depressive-like behavior in mice.  Genes Brain Behav 20(4):e12708.

Viitanen R, Moisio O, Lankinen P, Li XG, Koivumäki M, Suilamo S, Tolvanen T, Taimen K, Mali M, Kohonen I, Koskivirta I, Oikonen V, Virtanen H, Santalahti K, Autio A, Saraste A, Pirilä L, Nuutila P, Knuuti J, Jalkanen S, Roivainen A (2021) First-in-Humans Study of (68)Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1.  J Nucl Med 62(4):577-583.

Salomäki SP, Saraste A, Kemppainen J, Hurme S, Knuuti J, Nuutila P, Seppänen M, Roivainen A, Airaksinen J, Salo T, Oksi J, Pirilä L, Hohenthal U (2021) (18)F-FDG positron emission tomography/computed tomography of cardiac implantable electronic device infections.  J Nucl Cardiol 28(6):2992-3003.

Grönman M, Tarkia M, Stark C, Vähäsilta T, Kiviniemi T, Lubberink M, Halonen P, Kuivanen A, Saunavaara V, Tolvanen T, Teuho J, Teräs M, Savunen T, Pietilä M, Ylä-Herttuala S, Roivainen A, Knuuti J, Saraste A (2021) Assessment of myocardial viability with [(15)O]water PET: A validation study in experimental myocardial infarction.  J Nucl Cardiol 28(4):1271-1280.

Teuho J, Riehakainen L, Honkaniemi A, Moisio O, Han C, Tirri M, Liu S, Grönroos TJ, Liu J, Wan L, Liang X, Ling Y, Hua Y, Roivainen A, Knuuti J, Xie Q, Teräs M, D'Ascenzo N, Klén R (2020) Evaluation of image quality with four positron emitters and three preclinical PET/CT systems.  EJNMMI Res 10(1):155.

Moisio O, Palani S, Virta J, Elo P, Liljenbäck H, Tolvanen T, Käkelä M, Miner MG, Herre EA, Marjamäki P, Örd T, Heinäniemi M, Kaikkonen MU, Zhang F, Srinivasarao M, Knuuti J, Low PS, Saraste A, Li XG, Roivainen A (2020) Radiosynthesis and preclinical evaluation of [(68)Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages.  Sci Rep 10(1):13593.

Heikelä H, Ruohonen ST, Adam M, Viitanen R, Liljenbäck H, Eskola O, Gabriel M, Mairinoja L, Pessia A, Velagapudi V, Roivainen A, Zhang FP, Strauss L, Poutanen M (2020) Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice.  Am J Physiol Endocrinol Metab 319(3):E494-E508.

Virta J, Hellberg S, Liljenbäck H, Ståhle M, Silvola JMU, Huusko J, Söderström M, Knuuti J, Nuutila P, Ylä-Herttuala S, Gomez MF, Roivainen A, Saraste A (2020) Effects of dipeptidyl peptidase 4 inhibition on inflammation in atherosclerosis: A (18)F-fluorodeoxyglucose study of a mouse model of atherosclerosis and type 2 diabetes.  Atherosclerosis 305:64-72.

Ståhle M, Silvola JMU, Hellberg S, de Vries M, Quax PHA, Kroon J, Rinne P, de Jong A, Liljenbäck H, Savisto N, Wickman A, Stroes ESG, Ylä-Herttuala S, Saukko P, Abrahamsson T, Pettersson K, Knuuti J, Roivainen A, Saraste A (2020) Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice.  JACC Basic Transl Sci 5(4):360-373.

Jahandideh A, Uotila S, Ståhle M, Virta J, Li XG, Kytö V, Marjamäki P, Liljenbäck H, Taimen P, Oikonen V, Lehtonen J, Mäyränpää MI, Chen Q, Low PS, Knuuti J, Roivainen A, Saraste A (2020) Folate Receptor β-Targeted PET Imaging of Macrophages in Autoimmune Myocarditis.  J Nucl Med 61(11):1643-1649.

Roivainen A, Li XG, Ohrndorf S, van der Laken CJ (2020) In Vivo Imaging of Inflammation and Infection 2019.  Contrast Media Mol Imaging 2020:6824583.

Miner MW, Liljenbäck H, Virta J, Merisaari J, Oikonen V, Westermarck J, Li XG, Roivainen A (2020) (2S, 4R)-4-[(18)F]Fluoroglutamine for In vivo PET Imaging of Glioma Xenografts in Mice: an Evaluation of Multiple Pharmacokinetic Models.  Mol Imaging Biol 22(4):969-978.

Saraste A, Ståhle M, Roivainen A (2020) Evaluation of cardiac function by nuclear imaging in preclinical studies.  J Nucl Cardiol 27(4):1328-1330.

Autio A, Uotila S, Kiugel M, Kytö V, Liljenbäck H, Kudomi N, Oikonen V, Metsälä O, Helin S, Knuuti J, Saraste A, Roivainen A (2020) (68)Ga-DOTA chelate, a novel imaging agent for assessment of myocardial perfusion and infarction detection in a rodent model.  J Nucl Cardiol 27(3):891-898.

Ståhle M, Kytö V, Kiugel M, Liljenbäck H, Metsälä O, Käkelä M, Li XG, Oikonen V, Saukko P, Nuutila P, Knuuti J, Roivainen A, Saraste A (2020) Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using (68)Ga-NODAGA-exendin-4 positron emission tomography.  J Nucl Cardiol 27(6):2386-2397.

Elo P, Li XG, Liljenbäck H, Helin S, Teuho J, Koskensalo K, Saunavaara V, Marjamäki P, Oikonen V, Virta J, Chen Q, Low PS, Knuuti J, Jalkanen S, Airas L, Roivainen A (2019) Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats.  J Neuroinflammation 16(1):252.

Jødal L, Roivainen A, Oikonen V, Jalkanen S, Hansen SB, Afzelius P, Alstrup AKO, Nielsen OL, Jensen SB (2019) Kinetic Modelling of [(68)Ga]Ga-DOTA-Siglec-9 in Porcine Osteomyelitis and Soft Tissue Infections.  Molecules 24.

Taimen K, Salomäki SP, Hohenthal U, Mali M, Kajander S, Seppänen M, Nuutila P, Palomäki A, Roivainen A, Pirilä L, Kemppainen J (2019) The Clinical Impact of Using (18)F-FDG-PET/CT in the Diagnosis of Suspected Vasculitis: The Effect of Dose and Timing of Glucocorticoid Treatment.  Contrast Media Mol Imaging 2019:9157637.

Forsström S, Jackson CB, Carroll CJ, Kuronen M, Pirinen E, Pradhan S, Marmyleva A, Auranen M, Kleine IM, Khan NA, Roivainen A, Marjamäki P, Liljenbäck H, Wang L, Battersby BJ, Richter U, Velagapudi V, Nikkanen J, Euro L, Suomalainen A (2019) Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions.  Cell Metab 30(6):1040-1054.e7.

Teuho J, Han C, Riehakainen L, Honkaniemi A, Tirri M, Liljenbäck H, Virta J, Gu S, Liu S, Wan L, Teräs M, Roivainen A, Xie Q, Knuuti J (2019) NEMA NU 4-2008 and in vivo imaging performance of RAYCAN trans-PET/CT X5 small animal imaging system.  Phys Med Biol 64(11):115014.

Hellberg S, Silvola JMU, Liljenbäck H, Kiugel M, Eskola O, Hakovirta H, Hörkkö S, Morisson-Iveson V, Hirani E, Saukko P, Ylä-Herttuala S, Knuuti J, Saraste A, Roivainen A (2019) Amyloid-Targeting PET Tracer [(18)F]Flutemetamol Accumulates in Atherosclerotic Plaques.  Molecules 24.

Mäkilä J, Kiviniemi A, Saanijoki T, Liljenbäck H, Käkelä M, Jadhav S, Poijärvi-Virta P, Lönnberg H, Laitala-Leinonen T, Virta P, Roivainen A (2019) Noninvasive and Quantitative Monitoring of the Distributions and Kinetics of MicroRNA-Targeting Molecules in Vivo by Positron Emission Tomography.  Mol Pharm 16(4):1507-1515.

Siitonen R, Peuhu E, Autio A, Liljenbäck H, Mattila E, Metsälä O, Käkelä M, Saanijoki T, Dijkgraaf I, Jalkanen S, Ivaska J, Roivainen A (2019) (68)Ga-DOTA-E[c(RGDfK)](2) PET Imaging of SHARPIN-Regulated Integrin Activity in Mice.  J Nucl Med 60(10):1380-1387.

Hagert C, Siitonen R, Li XG, Liljenbäck H, Roivainen A, Holmdahl R (2019) Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure.  Clin Exp Immunol 196(3):383-391.

Wang F, Tarkkonen K, Nieminen-Pihala V, Nagano K, Majidi RA, Puolakkainen T, Rummukainen P, Lehto J, Roivainen A, Zhang FP, Mäkitie O, Baron R, Kiviranta R (2019) Mesenchymal Cell-Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation.  J Bone Miner Res 34(6):1129-1142.

Chrusciel P, Yatkin E, Li XG, Jaakkola UM, Knuuti J, Jalkanen S, Roivainen A (2019) Safety Study of Single-Dose Intravenously Administered DOTA-Siglec-9 Peptide in Sprague Dawley Rats.  Int J Toxicol 38(1):4-11.

Ballo H, Tarkia M, Haavisto M, Stark C, Strandberg M, Vähäsilta T, Saunavaara V, Tolvanen T, Teräs M, Hynninen VV, Savunen T, Roivainen A, Knuuti J, Saraste A (2019) Determinants of Myocardial Strain in Experimental Chronic Myocardial Infarction.  Ultrasound Med Biol 45(2):568-578.

Kiugel M, Hellberg S, Käkelä M, Liljenbäck H, Saanijoki T, Li XG, Tuomela J, Knuuti J, Saraste A, Roivainen A (2018) Evaluation of [(68)Ga]Ga-DOTA-TCTP-1 for the Detection of Metalloproteinase 2/9 Expression in Mouse Atherosclerotic Plaques.  Molecules 23.

Hellberg S, Liljenbäck H, Eskola O, Morisson-Iveson V, Morrison M, Trigg W, Saukko P, Ylä-Herttuala S, Knuuti J, Saraste A, Roivainen A (2018) Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with (18)F-GE-180, a Radiotracer for Translocator Protein (TSPO).  Contrast Media Mol Imaging 2018:9186902.

Silvola JMU, Li XG, Virta J, Marjamäki P, Liljenbäck H, Hytönen JP, Tarkia M, Saunavaara V, Hurme S, Palani S, Hakovirta H, Ylä-Herttuala S, Saukko P, Chen Q, Low PS, Knuuti J, Saraste A, Roivainen A (2018) Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.  Sci Rep 8(1):9720.

Roivainen A, Li XG, Nanni C, Cai W, Ohrndorf S (2018) In Vivo Imaging of Inflammation and Infection.  Contrast Media Mol Imaging 2018:3817871.

Elo P, Tadayon S, Liljenbäck H, Teuho J, Käkelä M, Koskensalo K, Saunavaara V, Virta J, Veres TZ, Kiviniemi A, Saraste A, Marjamäki P, Airas L, Jalkanen S, Roivainen A (2018) Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis.  J Neuroinflammation 15(1):128.

Lankinen P, Noponen T, Autio A, Luoto P, Frantzèn J, Löyttyniemi E, Hakanen AJ, Aro HT, Roivainen A (2018) A Comparative (68)Ga-Citrate and (68)Ga-Chloride PET/CT Imaging of Staphylococcus aureus Osteomyelitis in the Rat Tibia.  Contrast Media Mol Imaging 2018:9892604.

Slart RHJA (2018) FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC.  Eur J Nucl Med Mol Imaging 45(7):1250-1269.

Käkelä M, Luoto P, Viljanen T, Virtanen H, Liljenbäck H, Jalkanen S, Knuuti J, Roivainen A, Li XG (2018) Adventures in radiosynthesis of clinical grade [(68)Ga]Ga-DOTA-Siglec-9.  RSC Adv 8(15):8051-8056.

Moisio O, Siitonen R, Liljenbäck H, Suomela E, Jalkanen S, Li XG, Roivainen A (2018) Exploring Alternative Radiolabeling Strategies for Sialic Acid-Binding Immunoglobulin-Like Lectin 9 Peptide: [(68)Ga]Ga- and [(18)F]AlF-NOTA-Siglec-9.  Molecules 23.

Koffert J, Ståhle M, Karlsson H, Iozzo P, Salminen P, Roivainen A, Nuutila P (2018) Morbid obesity and type 2 diabetes alter intestinal fatty acid uptake and blood flow.  Diabetes Obes Metab 20(6):1384-1390.

Aro E, Seppänen M, Mäkelä KT, Luoto P, Roivainen A, Aro HT (2018) PET/CT to detect adverse reactions to metal debris in patients with metal-on-metal hip arthroplasty: an exploratory prospective study.  Clin Physiol Funct Imaging 38(5):847-855.

Pietikäinen A, Siitonen R, Liljenbäck H, Eskola O, Söderström M, Roivainen A, Hytönen J (2018) In vivo imaging of Lyme arthritis in mice by [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography.  Scand J Rheumatol 47(1):37-47.

Kiugel M, Kytö V, Saanijoki T, Liljenbäck H, Metsälä O, Ståhle M, Tuomela J, Li XG, Saukko P, Knuuti J, Roivainen A, Saraste A (2018) Evaluation of (68)Ga-labeled peptide tracer for detection of gelatinase expression after myocardial infarction in rat.  J Nucl Cardiol 25(4):1114-1123.

Virtanen H, Silvola JMU, Autio A, Li XG, Liljenbäck H, Hellberg S, Siitonen R, Ståhle M, Käkelä M, Airaksinen AJ, Helariutta K, Tolvanen T, Veres TZ, Saraste A, Knuuti J, Jalkanen S, Roivainen A (2017) Comparison of (68)Ga-DOTA-Siglec-9 and (18)F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry.  Contrast Media Mol Imaging 2017:7645070.

Siitonen R, Pietikäinen A, Liljenbäck H, Käkelä M, Söderström M, Jalkanen S, Hytönen J, Roivainen A (2017) Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice.  Arthritis Res Ther 19(1):254.

Salomäki SP, Kemppainen J, Hohenthal U, Luoto P, Eskola O, Nuutila P, Seppänen M, Pirilä L, Oksi J, Roivainen A (2017) Head-to-Head Comparison of (68)Ga-Citrate and (18)F-FDG PET/CT for Detection of Infectious Foci in Patients with Staphylococcus aureus Bacteraemia.  Contrast Media Mol Imaging 2017:3179607.

Keinänen O, Mäkilä EM, Lindgren R, Virtanen H, Liljenbäck H, Oikonen V, Sarparanta M, Molthoff C, Windhorst AD, Roivainen A, Salonen JJ, Airaksinen AJ (2017) Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles.  ACS Omega 2(1):62-69.

Grönman M, Tarkia M, Kiviniemi T, Halonen P, Kuivanen A, Savunen T, Tolvanen T, Teuho J, Käkelä M, Metsälä O, Pietilä M, Saukko P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A (2017) Imaging of α(v)β(3) integrin expression in experimental myocardial ischemia with [(68)Ga]NODAGA-RGD positron emission tomography.  J Transl Med 15(1):144.

Jensen SB, Käkelä M, Jødal L, Moisio O, Alstrup AKO, Jalkanen S, Roivainen A (2017) Exploring the radiosynthesis and in vitro characteristics of [(68) Ga]Ga-DOTA-Siglec-9.  J Labelled Comp Radiopharm 60(9):439-449.

Hellberg S, Sippola S, Liljenbäck H, Virta J, Silvola JMU, Ståhle M, Savisto N, Metso J, Jauhiainen M, Saukko P, Ylä-Herttuala S, Nuutila P, Knuuti J, Roivainen A, Saraste A (2017) Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [(18)F]FDG uptake in Ldlr(-/-)Apob(100/100) mice.  Atherosclerosis 263:369-376.

Stapel B, Kohlhaas M, Ricke-Hoch M, Haghikia A, Erschow S, Knuuti J, Silvola JM, Roivainen A, Saraste A, Nickel AG, Saar JA, Sieve I, Pietzsch S, Müller M, Bogeski I, Kappl R, Jauhiainen M, Thackeray JT, Scherr M, Bengel FM, Hagl C, Tudorache I, Bauersachs J, Maack C, Hilfiker-Kleiner D (2017) Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy.  Eur Heart J 38(5):349-361.

O'Farrell AC, Evans R, Silvola JM, Miller IS, Conroy E, Hector S, Cary M, Murray DW, Jarzabek MA, Maratha A, Alamanou M, Udupi GM, Shiels L, Pallaud C, Saraste A, Liljenbäck H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, McAuliffe FM, Rousseau JA, Lecomte R, Gascon S, Arany Z, Ky B, Force T, Knuuti J, Gallagher WM, Roivainen A, Byrne AT (2017) A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate.  PLoS One 12(1):e0169964.

Ballo H, Tarkia M, Haavisto M, Stark C, Strandberg M, Vähäsilta T, Saunavaara V, Tolvanen T, Teräs M, Hynninen VV, Savunen T, Roivainen A, Knuuti J, Saraste A (2017) Accuracy of echocardiographic area-length method in chronic myocardial infarction: comparison with cardiac CT in pigs.  Cardiovasc Ultrasound 15(1):1.

Hellberg S, Silvola JMU, Kiugel M, Liljenbäck H, Savisto N, Li XG, Thiele A, Lehmann L, Heinrich T, Vollmer S, Hakovirta H, Laine VJO, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A (2017) 18-kDa translocator protein ligand (18)F-FEMPA: Biodistribution and uptake into atherosclerotic plaques in mice.  J Nucl Cardiol 24(3):862-871.

Salomäki SP, Saraste A, Kemppainen J, Bax JJ, Knuuti J, Nuutila P, Seppänen M, Roivainen A, Airaksinen J, Pirilä L, Oksi J, Hohenthal U (2017) (18)F-FDG positron emission tomography/computed tomography in infective endocarditis.  J Nucl Cardiol 24(1):195-206.

Silvola JM, Virtanen H, Siitonen R, Hellberg S, Liljenbäck H, Metsälä O, Ståhle M, Saanijoki T, Käkelä M, Hakovirta H, Ylä-Herttuala S, Saukko P, Jauhiainen M, Veres TZ, Jalkanen S, Knuuti J, Saraste A, Roivainen A (2016) Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques.  Sci Rep 6:35089.

Li XG, Hagert C, Siitonen R, Virtanen H, Sareila O, Liljenbäck H, Tuisku J, Knuuti J, Bergman J, Holmdahl R, Roivainen A (2016) (18)F-Labeling of Mannan for Inflammation Research with Positron Emission Tomography.  ACS Med Chem Lett 7(9):826-30.

Haavisto M, Saraste A, Pirilä L, Hannukainen JC, Kalliokoski KK, Kirjavainen A, Kemppainen J, Möttönen T, Knuuti J, Yli-Kerttula T, Roivainen A (2016) Influence of triple disease modifying anti-rheumatic drug therapy on carotid artery inflammation in drug-naive patients with recent onset of rheumatoid arthritis.  Rheumatology (Oxford) 55(10):1777-85.

Autio A, Virtanen H, Tolvanen T, Liljenbäck H, Oikonen V, Saanijoki T, Siitonen R, Käkelä M, Schüssele A, Teräs M, Roivainen A (2016) Erratum to: Absorption, distribution and excretion of intravenously injected (68)Ge/(68)Ga generator eluate in healthy rats, and estimation of human radiation dosimetry.  EJNMMI Res 6(1):51.

Jadhav S, Käkelä M, Bourgery M, Rimpilä K, Liljenbäck H, Siitonen R, Mäkilä J, Laitala-Leinonen T, Poijärvi-Virta P, Lönnberg H, Roivainen A, Virta P (2016) In Vivo Bone-Targeting of Bis(phosphonate)-Conjugated Double Helical RNA Monitored by Positron Emission Tomography.  Mol Pharm 13(7):2588-95.

Chen DW, Jin Y, Zhao RM, Long LJ, Zhang J, Han CL, Roivainen A, Knuuti J, Jalkanen S, Wang JC (2016) Age-, sex- and glucose-dependent correlation of plasma soluble vascular adhesion protein-1 concentration with cardiovascular risk factors and subclinical atherosclerosis.  Eur Rev Med Pharmacol Sci 20(8):1544-58.

Retamal J, Sörensen J, Lubberink M, Suarez-Sipmann F, Borges JB, Feinstein R, Jalkanen S, Antoni G, Hedenstierna G, Roivainen A, Larsson A, Velikyan I (2016) Feasibility of (68)Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome.  Am J Nucl Med Mol Imaging 6(1):18-31.

Nikkanen J, Forsström S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamäki J, Roivainen A, Marjamäki P, Liljenbäck H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lönnqvist T, Sajantila A, Isohanni P, Tyynismaa H, Nomura DK, Battersby BJ, Velagapudi V, Carroll CJ, Suomalainen A (2016) Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.  Cell Metab 23(4):635-48.

Hellberg S, Silvola JM, Kiugel M, Liljenbäck H, Metsälä O, Viljanen T, Metso J, Jauhiainen M, Saukko P, Nuutila P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A (2016) Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer ¹⁸F-fluoromethylcholine.  Cardiovasc Diabetol 15:26.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M (2016) USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.  Sci Transl Med 8(323):323ra13.

Tarkia M, Stark C, Haavisto M, Kentala R, Vähäsilta T, Savunen T, Strandberg M, Saunavaara V, Tolvanen T, Teräs M, Pietilä M, Nyman L, Duvall E, Saukko P, Levijoki J, Roivainen A, Saraste A, Knuuti J (2016) Effect of levosimendan therapy on myocardial infarct size and left ventricular function after acute coronary occlusion.  Heart 102(6):465-71.

Jadhav S, Käkelä M, Mäkilä J, Kiugel M, Liljenbäck H, Virta J, Poijärvi-Virta P, Laitala-Leinonen T, Kytö V, Jalkanen S, Saraste A, Roivainen A, Lönnberg H, Virta P (2016) Synthesis and In Vivo PET Imaging of Hyaluronan Conjugates of Oligonucleotides.  Bioconjug Chem 27(2):391-403.

Rinne P, Hellberg S, Kiugel M, Virta J, Li XG, Käkelä M, Helariutta K, Luoto P, Liljenbäck H, Hakovirta H, Gardberg M, Airaksinen AJ, Knuuti J, Saraste A, Roivainen A (2016) Comparison of Somatostatin Receptor 2-Targeting PET Tracers in the Detection of Mouse Atherosclerotic Plaques.  Mol Imaging Biol 18(1):99-108.

Virtanen H, Autio A, Siitonen R, Liljenbäck H, Saanijoki T, Lankinen P, Mäkilä J, Käkelä M, Teuho J, Savisto N, Jaakkola K, Jalkanen S, Roivainen A (2015) 68Ga-DOTA-Siglec-9--a new imaging tool to detect synovitis.  Arthritis Res Ther 17:308.

Autio A, Virtanen H, Tolvanen T, Liljenbäck H, Oikonen V, Saanijoki T, Siitonen R, Käkelä M, Schüssele A, Teräs M, Roivainen A (2015) Absorption, distribution and excretion of intravenously injected (68)Ge/ (68)Ga generator eluate in healthy rats, and estimation of human radiation dosimetry.  EJNMMI Res 5(1):117.

Tarkia M, Saraste A, Stark C, Vähäsilta T, Savunen T, Strandberg M, Saunavaara V, Tolvanen T, Teuho J, Teräs M, Metsälä O, Rinne P, Heinonen I, Savisto N, Pietilä M, Saukko P, Roivainen A, Knuuti J (2015) [18F]FDG Accumulation in Early Coronary Atherosclerotic Lesions in Pigs.  PLoS One 10(6):e0131332.

Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J (2015) Enabling [(18)F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [(18)F]-anti-microRNA-21 as an example.  Chem Commun (Camb) 51(48):9821-4.

Kiviniemi A, Gardberg M, Frantzén J, Pesola M, Vuorinen V, Parkkola R, Tolvanen T, Suilamo S, Johansson J, Luoto P, Kemppainen J, Roivainen A, Minn H (2015) Somatostatin receptor subtype 2 in high-grade gliomas: PET/CT with (68)Ga-DOTA-peptides, correlation to prognostic markers, and implications for targeted radiotherapy.  EJNMMI Res 5:25.

Tarkia M, Stark C, Haavisto M, Kentala R, Vähäsilta T, Savunen T, Strandberg M, Hynninen VV, Saunavaara V, Tolvanen T, Teräs M, Rokka J, Pietilä M, Saukko P, Roivainen A, Saraste A, Knuuti J (2015) Cardiac remodeling in a new pig model of chronic heart failure: Assessment of left ventricular functional, metabolic, and structural changes using PET, CT, and echocardiography.  J Nucl Cardiol 22(4):655-65.

Lehto J, Virta JR, Oikonen V, Roivainen A, Luoto P, Arponen E, Helin S, Hietamäki J, Holopainen A, Kailajärvi M, Peltonen JM, Rouru J, Sallinen J, Virtanen K, Volanen I, Scheinin M, Rinne JO (2015) Test-retest reliability of (11)C-ORM-13070 in PET imaging of α2C-adrenoceptors in vivo in the human brain.  Eur J Nucl Med Mol Imaging 42(1):120-7.

Ahtinen H, Kulkova J, Lindholm L, Eerola E, Hakanen AJ, Moritz N, Söderström M, Saanijoki T, Jalkanen S, Roivainen A, Aro HT (2014) (68)Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections.  EJNMMI Res 4:45.

Mäkilä J, Jadhav S, Kiviniemi A, Käkelä M, Liljenbäck H, Poijärvi-Virta P, Laitala-Leinonen T, Lönnberg H, Roivainen A, Virta P (2014) Synthesis of multi-galactose-conjugated 2'-O-methyl oligoribonucleotides and their in vivo imaging with positron emission tomography.  Bioorg Med Chem 22(24):6806-13.

Uotila S, Silvola JM, Saukko P, Nuutila P, Heinonen SE, Ylä-Herttuala S, Roivainen A, Knuuti J, Saraste A (2014) [18F]fluorodeoxyglucose uptake in atherosclerotic plaques is associated with reduced coronary flow reserve in mice.  J Ultrasound Med 33(11):1941-8.

Autio A, Saraste A, Kudomi N, Saanijoki T, Johansson J, Liljenbäck H, Tarkia M, Oikonen V, Sipilä HT, Roivainen A (2014) Assessment of blood flow with (68)Ga-DOTA PET in experimental inflammation: a validation study using (15)O-water.  Am J Nucl Med Mol Imaging 4(6):571-9.

Salomäki SP, Kemppainen J, Aho H, Hohenthal U, Kain R, Koivuviita N, Badeau RM, Seppänen M, Silvoniemi A, Roivainen A, Pirilä L (2014) Widespread vascular inflammation in a patient with antineutrophil cytoplasmic antibody-associated vasculitis as detected by positron emission tomography.  Eur J Nucl Med Mol Imaging 41(11):2167-8.

Kiugel M, Dijkgraaf I, Kytö V, Helin S, Liljenbäck H, Saanijoki T, Yim CB, Oikonen V, Saukko P, Knuuti J, Roivainen A, Saraste A (2014) Dimeric [(68)Ga]DOTA-RGD peptide targeting αvβ 3 integrin reveals extracellular matrix alterations after myocardial infarction.  Mol Imaging Biol 16(6):793-801.

Chary K, Teuho J, Virta J, Sipilä H, Saunavaara V, Roivainen A, Teräs M (2014) Use of a clinical PET/MR scanner for preclinical research with first results.  EJNMMI Phys 1(Suppl 1):A88.

Kiviniemi A, Gardberg M, Autio A, Li XG, Heuser VD, Liljenbäck H, Käkelä M, Sipilä H, Kurkipuro J, Ylä-Herttuala S, Knuuti J, Minn H, Roivainen A (2014) Feasibility of experimental BT4C glioma models for somatostatin receptor 2-targeted therapies.  Acta Oncol 53(8):1125-34.

Luoto P, Suilamo S, Oikonen V, Arponen E, Helin S, Herttuainen J, Hietamäki J, Holopainen A, Kailajärvi M, Peltonen JM, Rouru J, Sallinen J, Scheinin M, Virta J, Virtanen K, Volanen I, Roivainen A, Rinne JO (2014) ¹¹C-ORM-13070, a novel PET ligand for brain α₂C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men.  Eur J Nucl Med Mol Imaging 41(10):1947-56.

Rinne P, Silvola JM, Hellberg S, Ståhle M, Liljenbäck H, Salomäki H, Koskinen E, Nuutinen S, Saukko P, Knuuti J, Saraste A, Roivainen A, Savontaus E (2014) Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice.  Arterioscler Thromb Vasc Biol 34(7):1346-54.

Honka H, Hannukainen JC, Tarkia M, Karlsson H, Saunavaara V, Salminen P, Soinio M, Mikkola K, Kudomi N, Oikonen V, Haaparanta-Solin M, Roivainen A, Parkkola R, Iozzo P, Nuutila P (2014) Pancreatic metabolism, blood flow, and β-cell function in obese humans.  J Clin Endocrinol Metab 99(6):E981-90.

Li XG, Helariutta K, Roivainen A, Jalkanen S, Knuuti J, Airaksinen AJ (2014) Using 5-deoxy-5-[18F]fluororibose to glycosylate peptides for positron emission tomography.  Nat Protoc 9(1):138-45.

Mikkola K, Yim CB, Fagerholm V, Ishizu T, Elomaa VV, Rajander J, Jurttila J, Saanijoki T, Tolvanen T, Tirri M, Gourni E, Béhé M, Gotthardt M, Reubi JC, Mäcke H, Roivainen A, Solin O, Nuutila P (2014) 64Cu- and 68Ga-labelled [Nle(14),Lys(40)(Ahx-NODAGA)NH2]-exendin-4 for pancreatic beta cell imaging in rats.  Mol Imaging Biol 16(2):255-63.

Koski A, Ahtinen H, Liljenback H, Roivainen A, Koskela A, Oksanen M, Partanen K, Laasonen L, Kairemo K, Joensuu T, Hemminki A (2013) [(18)F]-fluorodeoxyglucose positron emission tomography and computed tomography in response evaluation of oncolytic adenovirus treatments of patients with advanced cancer.  Hum Gene Ther 24(12):1029-41.

Kähkönen E, Jambor I, Kemppainen J, Lehtiö K, Grönroos TJ, Kuisma A, Luoto P, Sipilä HJ, Tolvanen T, Alanen K, Silén J, Kallajoki M, Roivainen A, Schäfer N, Schibli R, Dragic M, Johayem A, Valencia R, Borkowski S, Minn H (2013) In vivo imaging of prostate cancer using [68Ga]-labeled bombesin analog BAY86-7548.  Clin Cancer Res 19(19):5434-43.

Yim CB, Mikkola K, Fagerholm V, Elomaa VV, Ishizu T, Rajander J, Schlesinger J, Roivainen A, Nuutila P, Solin O (2013) Synthesis and preclinical characterization of [64Cu]NODAGA-MAL-exendin-4 with a Nε-maleoyl-L-lysyl-glycine linkage.  Nucl Med Biol 40(8):1006-12.

Autio A, Vainio PJ, Suilamo S, Mali A, Vainio J, Saanijoki T, Noponen T, Ahtinen H, Luoto P, Teräs M, Jalkanen S, Roivainen A (2013) Preclinical evaluation of a radioiodinated fully human antibody for in vivo imaging of vascular adhesion protein-1-positive vasculature in inflammation.  J Nucl Med 54(8):1315-9.

Kalliokoski S, Sulic AM, Korponay-Szabó IR, Szondy Z, Frias R, Perez MA, Martucciello S, Roivainen A, Pelliniemi LJ, Esposito C, Griffin M, Sblattero D, Mäki M, Kaukinen K, Lindfors K, Caja S (2013) Celiac Disease-Specific TG2-Targeted Autoantibodies Inhibit Angiogenesis Ex Vivo and In Vivo in Mice by Interfering with Endothelial Cell Dynamics.  PLoS One 8(6):e65887.

Roivainen A, Kähkönen E, Luoto P, Borkowski S, Hofmann B, Jambor I, Lehtiö K, Rantala T, Rottmann A, Sipilä H, Sparks R, Suilamo S, Tolvanen T, Valencia R, Minn H (2013) Plasma pharmacokinetics, whole-body distribution, metabolism, and radiation dosimetry of 68Ga bombesin antagonist BAY 86-7548 in healthy men.  J Nucl Med 54(6):867-72.

Li XG, Autio A, Ahtinen H, Helariutta K, Liljenbäck H, Jalkanen S, Roivainen A, Airaksinen AJ (2013) Translating the concept of peptide labeling with 5-deoxy-5-[18F]fluororibose into preclinical practice: 18F-labeling of Siglec-9 peptide for PET imaging of inflammation.  Chem Commun (Camb) 49(35):3682-3684.

Roivainen A, Naum A, Nuutinen H, Leino R, Nurmi H, Någren K, Parkkola R, Virtanen J, Kallajoki M, Kujari H, Ovaska J, Roberts P, Seppänen M (2013) Characterization of hepatic tumors using [11C]metomidate through positron emission tomography: comparison with [11C]acetate.  EJNMMI Res 3(1):13.

Autio A, Jalkanen S, Roivainen A (2013) Nuclear imaging of inflammation: homing-associated molecules as targets.  EJNMMI Res 3(1):1.

Roivainen A, Hautaniemi S, Möttönen T, Nuutila P, Oikonen V, Parkkola R, Pricop L, Ress R, Seneca N, Seppänen M, Yli-Kerttula T (2013) Correlation of 18F-FDG PET/CT assessments with disease activity and markers of inflammation in patients with early rheumatoid arthritis following the initiation of combination therapy with triple oral antirheumatic drugs.  Eur J Nucl Med Mol Imaging 40(3):403-10.

Kiviniemi A, Mäkelä J, Mäkilä J, Saanijoki T, Liljenbäck H, Poijärvi-Virta P, Lönnberg H, Laitala-Leinonen T, Roivainen A, Virta P (2012) Solid-supported NOTA and DOTA chelators useful for the synthesis of 3'-radiometalated oligonucleotides.  Bioconjug Chem 23(9):1981-8.

Lankinen P, Lehtimäki K, Hakanen AJ, Roivainen A, Aro HT (2012) A comparative 18F-FDG PET/CT imaging of experimental Staphylococcus aureus osteomyelitis and Staphylococcus epidermidis foreign-body-associated infection in the rabbit tibia.  EJNMMI Res 2(1):41.

Roivainen A, Jalkanen S, Nanni C (2012) Gallium-labelled peptides for imaging of inflammation.  Eur J Nucl Med Mol Imaging 39 Suppl 1:S68-77.

Tarkia M, Saraste A, Saanijoki T, Oikonen V, Vähäsilta T, Strandberg M, Stark C, Tolvanen T, Teräs M, Savunen T, Green MA, Knuuti J, Roivainen A (2012) Evaluation of 68Ga-labeled tracers for PET imaging of myocardial perfusion in pigs.  Nucl Med Biol 39(5):715-23.

Kudomi N, Sipilä H, Autio A, Oikonen V, Liljenbäck H, Tarkia M, Laivola J, Johansson J, Teräs M, Roivainen A (2012) Cross-validation of input functions obtained by H₂ 15O PET imaging of rat heart and a blood flow-through detector.  Mol Imaging Biol 14(4):509-16.

Autio A, Henttinen T, Sipilä HJ, Jalkanen S, Roivainen A (2011) Mini-PEG spacering of VAP-1-targeting 68Ga-DOTAVAP-P1 peptide improves PET imaging of inflammation.  EJNMMI Res 1(1):10.

Silvola JM, Laitinen I, Sipilä HJ, Laine VJ, Leppänen P, Ylä-Herttuala S, Knuuti J, Roivainen A (2011) Uptake of 68gallium in atherosclerotic plaques in LDLR-/-ApoB100/100 mice.  EJNMMI Res 1(1):14.

Silvola JM, Saraste A, Laitinen I, Savisto N, Laine VJ, Heinonen SE, Ylä-Herttuala S, Saukko P, Nuutila P, Roivainen A, Knuuti J (2011) Effects of age, diet, and type 2 diabetes on the development and FDG uptake of atherosclerotic plaques.  JACC Cardiovasc Imaging 4(12):1294-301.

Aalto K, Autio A, Kiss EA, Elima K, Nymalm Y, Veres TZ, Marttila-Ichihara F, Elovaara H, Saanijoki T, Crocker PR, Maksimow M, Bligt E, Salminen TA, Salmi M, Roivainen A, Jalkanen S (2011) Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer.  Blood 118(13):3725-33.

Silvola JM, Saraste A, Forsback S, Laine VJ, Saukko P, Heinonen SE, Ylä-Herttuala S, Roivainen A, Knuuti J (2011) Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.  Arterioscler Thromb Vasc Biol 31(5):1011-5.

Kudomi N, Bucci M, Oikonen V, Silvennoinen M, Kainulainen H, Nuutila P, Iozzo P, Roivainen A (2011) Extraction of input function from rat [18F]FDG PET images.  Mol Imaging Biol 13(6):1241-9.

Ujula T, Huttunen M, Luoto P, Peräkylä H, Simpura I, Wilson I, Bergman M, Roivainen A (2010) Matrix metalloproteinase 9 targeting peptides: syntheses, 68Ga-labeling, and preliminary evaluation in a rat melanoma xenograft model.  Bioconjug Chem 21(9):1612-21.

Iozzo P, Bucci M, Roivainen A, Någren K, Järvisalo MJ, Kiss J, Guiducci L, Fielding B, Naum AG, Borra R, Virtanen K, Savunen T, Salvadori PA, Ferrannini E, Knuuti J, Nuutila P (2010) Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals.  Gastroenterology 139(3):846-56, 856.e1-6.

Autio A, Ujula T, Luoto P, Salomäki S, Jalkanen S, Roivainen A (2010) PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG.  Eur J Nucl Med Mol Imaging 37(10):1918-25.

Laitinen IE, Luoto P, Någren K, Marjamäki PM, Silvola JM, Hellberg S, Laine VJ, Ylä-Herttuala S, Knuuti J, Roivainen A (2010) Uptake of 11C-choline in mouse atherosclerotic plaques.  J Nucl Med 51(5):798-802.

Tolvanen T, Yli-Kerttula T, Ujula T, Autio A, Lehikoinen P, Minn H, Roivainen A (2010) Biodistribution and radiation dosimetry of [(11)C]choline: a comparison between rat and human data.  Eur J Nucl Med Mol Imaging 37(5):874-83.

Luoto P, Laitinen I, Suilamo S, Någren K, Roivainen A (2010) Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats.  Mol Imaging Biol 12(4):435-42.

Hirvonen J, Roivainen A, Virta J, Helin S, Någren K, Rinne JO (2010) Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation.  Eur J Nucl Med Mol Imaging 37(3):606-12.

Silvola J, Autio A, Luoto P, Jalkanen S, Roivainen A (2010) Preliminary evaluation of novel 68Ga-DOTAVAP-PEG-P2 peptide targeting vascular adhesion protein-1.  Clin Physiol Funct Imaging 30(1):75-8.

Ujula T, Salomäki S, Autio A, Luoto P, Tolvanen T, Lehikoinen P, Viljanen T, Sipilä H, Härkönen P, Roivainen A (2010) 68Ga-chloride PET reveals human pancreatic adenocarcinoma xenografts in rats--comparison with FDG.  Mol Imaging Biol 12(3):259-68.

Ujula T, Salomäki S, Virsu P, Lankinen P, Mäkinen TJ, Autio A, Yegutkin GG, Knuuti J, Jalkanen S, Roivainen A (2009) Synthesis, 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitis.  Nucl Med Biol 36(6):631-41.

Johanna Haukkala, Iina Laitinen, Pauliina Luoto, Peter Iveson, Ian Wilson, Hege Karlsen, Alan Cuthbertson, Jukka Laine, Pia Leppänen, Ylä-Herttula S, Knuuti J, Roivainen A (2009) 68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice.  Eur J Nucl Med Mol Imaging 36(12):2058-67.

Roivainen A, Någren K, Hirvonen J, Oikonen V, Virsu P, Tolvanen T, Rinne JO (2009) Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography.  Eur J Nucl Med Mol Imaging 36(4):671-82.

Laitinen I, Marjamäki P, Någren K, Laine VJ, Wilson I, Leppänen P, Ylä-Herttuala S, Roivainen A, Knuuti J (2009) Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques.  Eur J Nucl Med Mol Imaging 36(1):73-80.

Virta JR, Tolvanen T, Någren K, Brück A, Roivainen A, Rinne JO (2008) 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation.  J Nucl Med 49(3):347-53.

Kalliokoski T, Nuutila P, Virtanen KA, Iozzo P, Bucci M, Svedström E, Roivainen A, Någren K, Viljanen T, Minn H, Knuuti J, Rönnemaa T, Simell O (2008) Pancreatic glucose uptake in vivo in men with newly diagnosed type 1 diabetes.  J Clin Endocrinol Metab 93(5):1909-14.

Hirvonen J, Johansson J, Teräs M, Oikonen V, Lumme V, Virsu P, Roivainen A, Någren K, Halldin C, Farde L, Hietala J (2008) Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility.  J Cereb Blood Flow Metab 28(5):1059-69.

Lankinen P, Mäkinen TJ, Pöyhönen TA, Virsu P, Salomäki S, Hakanen AJ, Jalkanen S, Aro HT, Roivainen A (2008) (68)Ga-DOTAVAP-P1 PET imaging capable of demonstrating the phase of inflammation in healing bones and the progress of infection in osteomyelitic bones.  Eur J Nucl Med Mol Imaging 35(2):352-64.

Roivainen A, Yli-Kerttula T (2006) Whole-body distribution of (11)C-choline and uptake in knee synovitis.  Eur J Nucl Med Mol Imaging 33(11):1372-3.

Laitinen I, Marjamäki P, Haaparanta M, Savisto N, Laine VJ, Soini SL, Wilson I, Leppänen P, Ylä-Herttuala S, Roivainen A, Knuuti J (2006) Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: experimental study of mouse and human arteries.  Eur J Nucl Med Mol Imaging 33(12):1461-7.

Mäkinen TJ, Lankinen P, Pöyhönen T, Jalava J, Aro HT, Roivainen A (2005) Comparison of 18F-FDG and 68Ga PET imaging in the assessment of experimental osteomyelitis due to Staphylococcus aureus.  Eur J Nucl Med Mol Imaging 32(11):1259-68.

Lendvai G, Velikyan I, Bergström M, Estrada S, Laryea D, Välilä M, Salomäki S, Långström B, Roivainen A (2005) Biodistribution of 68Ga-labelled phosphodiester, phosphorothioate, and 2'-O-methyl phosphodiester oligonucleotides in normal rats.  Eur J Pharm Sci 26(1):26-38.

Roivainen A, Rinne J, Virta J, Järvenpää T, Salomäki S, Yu M, Någren K (2004) Biodistribution and blood metabolism of 1-11C-methyl-4-piperidinyl n-butyrate in humans: an imaging agent for in vivo assessment of butyrylcholinesterase activity with PET.  J Nucl Med 45(12):2032-9.

Minn H, Salonen A, Friberg J, Roivainen A, Viljanen T, Långsjö J, Salmi J, Välimäki M, Någren K, Nuutila P (2004) Imaging of adrenal incidentalomas with PET using (11)C-metomidate and (18)F-FDG.  J Nucl Med 45(6):972-9.

Roivainen A, Tolvanen T, Salomäki S, Lendvai G, Velikyan I, Numminen P, Välilä M, Sipilä H, Bergström M, Härkönen P, Lönnberg H, Långström B (2004) 68Ga-labeled oligonucleotides for in vivo imaging with PET.  J Nucl Med 45(2):347-55.

Sutinen E, Nurmi M, Roivainen A, Varpula M, Tolvanen T, Lehikoinen P, Minn H (2004) Kinetics of [(11)C]choline uptake in prostate cancer: a PET study.  Eur J Nucl Med Mol Imaging 31(3):317-24.

Roivainen A, Parkkola R, Yli-Kerttula T, Lehikoinen P, Viljanen T, Möttönen T, Nuutila P, Minn H (2003) Use of positron emission tomography with methyl-11C-choline and 2-18F-fluoro-2-deoxy-D-glucose in comparison with magnetic resonance imaging for the assessment of inflammatory proliferation of synovium.  Arthritis Rheum 48(11):3077-84.

Utriainen M, Komu M, Vuorinen V, Lehikoinen P, Sonninen P, Kurki T, Utriainen T, Roivainen A, Kalimo H, Minn H (2003) Evaluation of brain tumor metabolism with [11C]choline PET and 1H-MRS.  J Neurooncol 62(3):329-38.

Rinne JO, Kaasinen V, Järvenpää T, Någren K, Roivainen A, Yu M, Oikonen V, Kurki T (2003) Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease.  J Neurol Neurosurg Psychiatry 74(1):113-5.

Lehtiö K, Oikonen V, Nyman S, Grönroos T, Roivainen A, Eskola O, Minn H (2003) Quantifying tumour hypoxia with fluorine-18 fluoroerythronitroimidazole ([18F]FETNIM) and PET using the tumour to plasma ratio.  Eur J Nucl Med Mol Imaging 30(1):101-8.

Kaasinen V, Någren K, Järvenpää T, Roivainen A, Yu M, Oikonen V, Kurki T, Rinne JO (2002) Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease.  J Clin Psychopharmacol 22(6):615-20.

Roivainen A, Zhu F, Sipola E, Yli-Jama T, Toivanen P (2001) Failure to verify H-ras mutations in arthritic synovium: comment on the article by Roivainen et al.  Arthritis Rheum 44(11):2705.

Pirilä L, Aho H, Roivainen A, Konttinen YT, Pelliniemi LJ, Heino J (2001) Identification of alpha6beta1 integrin positive cells in synovial lining layer as type B synoviocytes.  J Rheumatol 28(3):478-84.

Roivainen A, Forsback S, Grönroos T, Lehikoinen P, Kähkönen M, Sutinen E, Minn H (2000) Blood metabolism of [methyl-11C]choline; implications for in vivo imaging with positron emission tomography.  Eur J Nucl Med 27(1):25-32.

Roivainen A, Pirilä L, Yli-Jama T, Laaksonen H, Toivanen P (1999) Expression of the myc-family proto-oncogenes and related genes max and mad in synovial tissue.  Scand J Rheumatol 28(5):314-8.

Roivainen A, Jalava J, Pirilä L, Yli-Jama T, Tiusanen H, Toivanen P (1997) H-ras oncogene point mutations in arthritic synovium.  Arthritis Rheum 40(9):1636-43.

Roivainen A, Söderström KO, Pirilä L, Aro H, Kortekangas P, Merilahti-Palo R, Yli-Jama T, Toivanen A, Toivanen P (1996) Oncoprotein expression in human synovial tissue: an immunohistochemical study of different types of arthritis.  Br J Rheumatol 35(10):933-42.

Isomäki P, Söderström KO, Punnonen J, Roivainen A, Luukkainen R, Merilahti-Palo R, Nikkari S, Lassila O, Toivanen P (1996) Expression of bcl-2 in rheumatoid arthritis.  Br J Rheumatol 35(7):611-9.

Roivainen A, Isomäki P, Nikkari S, Saario R, Vuori K, Toivanen P (1995) Oncogene expression in synovial fluid cells in reactive and early rheumatoid arthritis: a brief report.  Br J Rheumatol 34(9):805-8.

Nikkari S, Roivainen A, Hannonen P, Möttönen T, Luukkainen R, Yli-Jama T, Toivanen P (1995) Persistence of parvovirus B19 in synovial fluid and bone marrow.  Ann Rheum Dis 54(7):597-600.

Publication list retrieved from NCBI using ImpactPubs

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